The processing framework only requires two linked service connections giving the orchestrator access to the SQL database and the Azure Functions App. Both can then optional be used with a third linked service connection to Azure Key Vault (which is recommended).
For more granular security models you could use Function level key instead of the top level Function App service key. In which case, more linked service connection maybe required per Function activity request. Unless you wish to handle this dynamically. The framework doesn’t have a specific requirement.
Depending on your preferred setup the default, hosted or tailored intergration runtime (IR) can be used for these linked service. The framework doesn’t have a specific requirement for the IR. Only that connectivity is possible.